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Holy! Water – Enhanced Ketone Hydration

 

Scientific basis for our formula.

 

The purpose of Holy! Water is to provide tools for a healthy life, focusing on metabolic health, physical health and performance and brain health, focus and cognition.  Ketones are a fantastic tool to achieve this goal.

 

Our “secret sauce” is the ketogenic ester (R)-1,3,-butanediol.  This ester is converted into the ketone, beta-hydroxybutyrate, which is used to make ATP.

 

Ketone esters:

Ketone esters, a type of exogenous ketone, have gained attention for their potential benefits in various aspects of health and performance. Here's an expanded summary highlighting the benefits of ketone esters:

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10324611/

 

Enhanced Physical Performance: Ketone esters have been shown to enhance physical performance by providing an efficient and readily available energy source. During exercise, ketone esters can increase the levels of circulating ketones in the blood, which can be used by muscles as fuel. This can potentially delay the onset of fatigue, improve endurance, and enhance recovery post-exercise.

 

https://journals.humankinetics.com/view/journals/ijsnem/29/5/article-p466.xml

 

Cognitive Function: Research suggests that ketone esters may have cognitive-enhancing effects, particularly in conditions where brain energy metabolism is impaired. By providing an alternative fuel source to glucose, ketones derived from ketone esters can improve cognitive function, including memory, focus, and mental clarity. This has implications for enhancing cognitive performance in healthy individuals as well as those with neurodegenerative conditions such as Alzheimer's disease.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840718/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286979/

 

Metabolic Health: Ketone esters have been investigated for their potential metabolic benefits, including promoting weight loss and improving metabolic markers such as blood sugar levels and insulin sensitivity. By inducing a state of ketosis, ketone esters can increase fat oxidation and suppress appetite, leading to greater weight loss compared to traditional low-fat diets. Ketone esters may help regulate blood glucose levels, making them a promising therapeutic option for individuals with insulin resistance or type 2 diabetes.

Weight Management: Ketone esters may help in managing weight by promoting a state of ketosis, where the body burns fat for fuel instead of carbohydrates. This can lead to reduced hunger and decreased fat storage, although the exact mechanisms and long-term effectiveness need more research.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338649/

 

Blood Sugar Regulation: By providing a direct source of energy that does not rely on glucose, ketone esters can help stabilize blood sugar levels. This may be particularly beneficial for individuals with type 2 diabetes or those at risk of developing diabetes.

 

https://www.ahajournals.org/doi/10.1161/JAHA.120.020729

 

Reduced Inflammation: Some studies suggest that ketosis can lead to reduced levels of inflammation in the body. This could have implications for chronic inflammatory conditions, although more research is needed to fully understand this relationship.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981249/

 

 

Therapeutic Applications: Ketone esters show promise as therapeutic agents for various health conditions. For example, they have been studied for their potential neuroprotective effects in neurological disorders such as epilepsy, Parkinson's disease, and traumatic brain injury.  Some studies suggest that following the Keto diet can have benefits against diabetes, cancer, epilepsy, and Alzheimer’s by reducing blood sugar and Insulin levels and decreasing insulin resistance. A Keto diet can also effective weight loss and lower blood pressure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119973/

 

Exogenous ketone esters:

  • Better source of energy than glucose because it’s more efficient in producing ATP from ketones rather than glucose.

  • Alternative fuel used by body when fasted or in a low carb/sugar diet.

  • Used by fuel in the brain. May reduce age related cognitive deterioration.

  • Lowers blood sugar

  • Lowers hunger hormones – appetite suppressant

  • Better fuel to starve unhealthy cells like cancer cells, which primarily live off of glucose.

 

Ketone vs Glucose for metabolic efficiency

 

The efficiency of ATP production from ketones compared to glucose involves several factors, including the amount of ATP produced per molecule of substrate and the oxygen consumption required for their metabolism. Here's a breakdown of the efficiency of each:

 

1. ATP Yield:

   - Glucose: The complete oxidation of one molecule of glucose through glycolysis, the citric acid cycle (Krebs cycle), and oxidative phosphorylation yields about 30 to 32 molecules of ATP.

   - Ketones: Ketone bodies, such as beta-hydroxybutyrate (BHB) and acetoacetate, can also be converted into acetyl-CoA and enter the citric acid cycle. The ATP yield from ketone metabolism is slightly higher than glucose on a per carbon basis because ketones are already in a more "oxidized" form compared to glucose. For example, the complete oxidation of acetoacetate to CO2 and H2O produces approximately 10 ATP molecules. Given that ketones are efficiently metabolized and have fewer carbon atoms than glucose, their ATP yield relative to their carbon content is high.

 

2. Oxygen Efficiency:

The amount of oxygen required to produce ATP from ketones is generally lower than that required for glucose, making ketone metabolism potentially more "oxygen-efficient." This means that, under conditions where oxygen is limited (such as during intense physical activity), ketones might produce more ATP per unit of oxygen consumed than glucose.

 

3. Energy Density:

   - Ketones are a more energy-dense source of fuel than glucose, providing a higher amount of energy per gram. This can make them an efficient fuel source, especially during prolonged periods of fasting or in conditions such as a ketogenic diet, where the body relies more on fat and ketone bodies for energy.

 

4. Metabolic Conditions:

   - The body's preference for glucose or ketones varies depending on the metabolic conditions. For example, during regular feeding conditions, glucose is the primary energy source for many cells. However, during fasting, prolonged exercise, or a ketogenic diet, the liver increases ketone production, and ketones become an important energy source, particularly for the brain.

 

Summary

 

What are ketones:

  • Generated from fatty acids in a process called ketogenesis

  • Fuel used to create ATP as an alternative to glucose

  • When in a fasted state or a low carbohydrate diet.

  • Used by brain and muscle for energy

 

 

Enhanced physical performance

  • Efficient and readily available energy source

  • Used by muscles as fuel

  • Delay onset of fatigue

  • Enhance recovery post-exercise

 

Cognitive function:

  • Alternative fuel source to glucose

  • Memory

  • Focus

  • Mental clarity

 

Metabolic health

  • Promote weight loss

  • Drop blood sugar levels

  • Stabilize insulin sensitivity

  • Reduce hunger hormones – appetite suppressant

 

Therapeutic applications:

  • Neuroprotective

  • Potential positive effect in neurological disorders

  • Anti-inflammatory effects

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